Human SLC17A5 protein (Recombinant) (N-His) (STJP006349)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC17A5-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC17A5 |
| Gene ID | 26503 |
| Uniprot ID | S17A5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr146-Phe405 |
Additional Info
| Function | Multifunctional anion transporter that operates via two distinct transport mechanisms, namely proton-coupled anion cotransport and membrane potential-dependent anion transport. Electroneutral proton-coupled acidic monosaccharide symporter, with a sugar to proton stoichiometry of 1:1. Exports glucuronic acid and free sialic acid derived from sialoglycoconjugate degradation out of lysosomes, driven by outwardly directed lysosomal pH gradient. May regulate lysosome function and metabolism of sialylated conjugates that impact oligodendrocyte lineage differentiation and myelinogenesis in the central nervous system. Electrogenic proton-coupled nitrate symporter that transports nitrate ions across the basolateral membrane of salivary gland acinar cells, with nitrate to proton stoichiometry of 2:1. May contribute to nitrate clearance from serum by salivary glands, where it is further concentrated and secreted in the saliva. Uses membrane potential to drive the uptake of acidic amino acids and peptides into synaptic vesicles. Responsible for synaptic vesicular storage of L-aspartate and L-glutamate in pinealocytes as well as vesicular uptake of N-acetyl-L-aspartyl-L-glutamate neuropeptide, relevant to aspartegic-associated glutamatergic neurotransmission and activation of metabotropic receptors that inhibit subsequent transmitter release. Receptor for CM101, a polysaccharide produced by group B Streptococcus with antipathoangiogenic properties. |
| Protein Name | SialinH(+/Nitrate CotransporterH(+/Sialic Acid CotransporterAstMembrane Glycoprotein Hp59Solute Carrier Family 17 Member 5Vesicular Excitatory Amino Acid TransporterVeat |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-428643Reactome: R-HSA-5619035 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneLysosome Membrane |
| Alternative Protein Names | Sialin proteinH(+/Nitrate Cotransporter proteinH(+/Sialic Acid Cotransporter proteinAst proteinMembrane Glycoprotein Hp59 proteinSolute Carrier Family 17 Member 5 proteinVesicular Excitatory Amino Acid Transporter proteinVeat proteinSLC17A5 protein |
Information sourced from Uniprot.org