Human SLC12A3 protein (Recombinant) (N-His) (STJP004946)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SLC12A3-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SLC12A3 |
| Gene ID | 6559 |
| Uniprot ID | S12A3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu3-Cys146 |
Additional Info
| Post Translational Modifications | Ubiquitinated.ubiquitination is essential for regulation of endocytosis. The BCR(KLHL3) complex was initially identified as a candidate ubiquitin ligase for SLC12A3. However, it was later shown that it is not the case. Phosphorylated at Thr-46, Thr-55, Thr-60 and Ser-91 by OXSR1/OSR1 and STK39/SPAK downstream of WNK4, promoting its activity. Phosphorylated in response to IL18. |
| Function | Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1. |
| Protein Name | Solute Carrier Family 12 Member 3Na-Cl CotransporterNccNa-Cl SymporterThiazide-Sensitive Sodium-Chloride Cotransporter |
| Database Links | Reactome: R-HSA-426117Reactome: R-HSA-5619087 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell Membrane |
| Alternative Protein Names | Solute Carrier Family 12 Member 3 proteinNa-Cl Cotransporter proteinNcc proteinNa-Cl Symporter proteinThiazide-Sensitive Sodium-Chloride Cotransporter proteinSLC12A3 proteinNCC proteinTSC protein |
Information sourced from Uniprot.org