Human SLC12A3 protein (Recombinant) (N-His) (STJP004946)

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STJP004946
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SLC12A3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SLC12A3
Gene ID: 6559
Uniprot ID: S12A3_HUMAN
Immunogen Region: Glu3-Cys146
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated.ubiquitination is essential for regulation of endocytosis. The BCR(KLHL3) complex was initially identified as a candidate ubiquitin ligase for SLC12A3. However, it was later shown that it is not the case. Phosphorylated at Thr-46, Thr-55, Thr-60 and Ser-91 by OXSR1/OSR1 and STK39/SPAK downstream of WNK4, promoting its activity. Phosphorylated in response to IL18.
Function Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1.
Protein Name Solute Carrier Family 12 Member 3
Na-Cl Cotransporter
Ncc
Na-Cl Symporter
Thiazide-Sensitive Sodium-Chloride Cotransporter
Database Links Reactome: R-HSA-426117
Reactome: R-HSA-5619087
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Apical Cell Membrane
Alternative Protein Names Solute Carrier Family 12 Member 3 protein
Na-Cl Cotransporter protein
Ncc protein
Na-Cl Symporter protein
Thiazide-Sensitive Sodium-Chloride Cotransporter protein
SLC12A3 protein
NCC protein
TSC protein

Information sourced from Uniprot.org