• Biotinylated Human SLAMF7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human SLAMF7 is greater than 95% as determined by SEC-HPLC.
  • Immobilized Biotinylated Human SLAMF7, His Tag at 1 Mu g/ml (100 Mu l/well) on the plate. Dose response curve for Anti-SLAMF7 Antibody, hFc Tag with the EC50 of 21. 8ng/ml determined by ELISA.

Human SLAMF7/CRACC/CD319 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001580)

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STJP001580

€773.13 - €2,386.88
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human SLAMF7/CRACC/CD319-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: SLAMF7
Gene ID: 57823
Uniprot ID: SLAF7_HUMAN
Immunogen Region: Ser23-Met226
Immunogen: DNA sequence encoding Human SLAMF7/CRACC/CD319 including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines. Isoform 3 does not mediate any NK cell activation.
Protein Name Slam Family Member 7
Cd2 Subset 1
Cd2-Like Receptor-Activating Cytotoxic Cells
Cracc
Membrane Protein Foap-12
Novel Ly9
Protein 19a
Cd Antigen Cd319
Database Links Reactome: R-HSA-198933
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Slam Family Member 7 protein
Cd2 Subset 1 protein
Cd2-Like Receptor-Activating Cytotoxic Cells protein
Cracc protein
Membrane Protein Foap-12 protein
Novel Ly9 protein
Protein 19a protein
Cd Antigen Cd319 protein
SLAMF7 protein
CS1 protein
UNQ576 protein
PRO1138 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance