| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, NBN, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration. Following phosphorylation in response to DNA damage, mediates 'Lys-63'-linked ubiquitination of NBN, promoting ATM recruitment to DNA damage sites and DNA repair via homologous recombination. Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus. |
| Protein Name | S-Phase Kinase-Associated Protein 2Cyclin-A/Cdk2-Associated Protein P45F-Box Protein Skp2F-Box/Lrr-Repeat Protein 1P45skp2 |
| Database Links | Reactome: R-HSA-174178Reactome: R-HSA-187577Reactome: R-HSA-5689880Reactome: R-HSA-68949Reactome: R-HSA-69231Reactome: R-HSA-8939902Reactome: R-HSA-8951664Reactome: R-HSA-9687136Reactome: R-HSA-9708530Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | S-Phase Kinase-Associated Protein 2 proteinCyclin-A/Cdk2-Associated Protein P45 proteinF-Box Protein Skp2 proteinF-Box/Lrr-Repeat Protein 1 proteinP45skp2 proteinSKP2 proteinFBXL1 protein |
Information sourced from Uniprot.org
