| Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. |
| Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. |
| Protein Name | Signal-Regulatory Protein GammaSirp-GammaCd172 Antigen-Like Family Member BSignal-Regulatory Protein Beta-2Sirp-B2Sirp-Beta-2Cd Antigen Cd172g |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-391160 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Signal-Regulatory Protein Gamma proteinSirp-Gamma proteinCd172 Antigen-Like Family Member B proteinSignal-Regulatory Protein Beta-2 proteinSirp-B2 proteinSirp-Beta-2 proteinCd Antigen Cd172g proteinSIRPG proteinSIRPB2 protein |
Information sourced from Uniprot.org
