Human SIRP-gamma/CD172g protein (Recombinant) (C-His&Avi) (STJP019824)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human SIRP-gamma/CD172g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu29-Pro360) of Human SIRP-gamma/CD172g (Accession #Q9P1W8) fused with a C-His&Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human SIRP-gamma/CD172g-C-His&Avi protein was developed in hek293 cells using the region Glu29-Pro360. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SIRPG |
| Gene ID | 55423 |
| Uniprot ID | SIRPG_HUMAN |
| Immunogen | Recombinant Human SIRP-gamma/CD172g Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu29-Pro360) of Human SIRP-gamma/CD172g (Accession #Q9P1W8) fused with a C-His&Avi tag at the C-terminus. |
| Immunogen Region | Glu29-Pro360 |
| Immunogen Sequence | EELQMIQPEKLLLVTVGKTA TLHCTVTSLLPVGPVLWFRG VGPGRELIYNQKEGHFPRVT TVSDLTKRNNMDFSIRISSI TPADVGTYYCVKFRKGSPEN VEFKSGPGTEMALGAKPSAP VVLGPAARTTPEHTVSFTCE SHGFSPRDITLKWFKNGNEL SDFQTNVDPTGQSVAYSIRS TARVVLDPWDVRSQVICEVA HVTLQGDPLRGTANLSEAIR VPPTLEVTQQPMRVGNQVN |
Additional Info
| Tissue Specificity | Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection. |
| Function | Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. |
| Protein Name | Signal-Regulatory Protein GammaSirp-GammaCd172 Antigen-Like Family Member BSignal-Regulatory Protein Beta-2Sirp-B2Sirp-Beta-2Cd Antigen Cd172g |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-391160 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Signal-Regulatory Protein Gamma proteinSirp-Gamma proteinCd172 Antigen-Like Family Member B proteinSignal-Regulatory Protein Beta-2 proteinSirp-B2 proteinSirp-Beta-2 proteinCd Antigen Cd172g proteinSIRPG proteinSIRPB2 protein |
Information sourced from Uniprot.org