| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 5Siglec-5Cd33 Antigen-Like 2Obesity-Binding Protein 2Ob-Bp2Ob-Binding Protein 2Cd Antigen Cd170 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Sialic Acid-Binding Ig-Like Lectin 5 proteinSiglec-5 proteinCd33 Antigen-Like 2 proteinObesity-Binding Protein 2 proteinOb-Bp2 proteinOb-Binding Protein 2 proteinCd Antigen Cd170 proteinSIGLEC5 proteinCD33L2 proteinOBBP2 protein |
Information sourced from Uniprot.org
