Human SHP/NR0B2 protein (Recombinant) (N-His) (STJP005452)

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STJP005452
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SHP/NR0B2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: NR0B2
Gene ID: 8431
Uniprot ID: NR0B2_HUMAN
Immunogen Region: Met1-Arg257
Immunogen: Homo sapiens (Human)
Post Translational Modifications Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.
Function Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14.
Protein Name Nuclear Receptor Subfamily 0 Group B Member 2
Orphan Nuclear Receptor Shp
Small Heterodimer Partner
Database Links Reactome: R-HSA-383280
Cellular Localisation Nucleus
Cytoplasm
Colocalizes With Neurod1 In The Nucleus
Alternative Protein Names Nuclear Receptor Subfamily 0 Group B Member 2 protein
Orphan Nuclear Receptor Shp protein
Small Heterodimer Partner protein
NR0B2 protein
SHP protein

Information sourced from Uniprot.org

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