Human SGPL1 protein (Recombinant) (N-His) (STJP003432)

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STJP003432
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SGPL1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SGPL1
Gene ID: 8879
Uniprot ID: SGPL1_HUMAN
Immunogen Region: Gln239-Arg493
Immunogen: Homo sapiens (Human)
Function Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
Protein Name Sphingosine-1-Phosphate Lyase 1
S1pl
Sp-Lyase 1
Spl 1
Hspl
Sphingosine-1-Phosphate Aldolase
Database Links Reactome: R-HSA-9845614
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iii Membrane Protein
Cytoplasmic Side
Alternative Protein Names Sphingosine-1-Phosphate Lyase 1 protein
S1pl protein
Sp-Lyase 1 protein
Spl 1 protein
Hspl protein
Sphingosine-1-Phosphate Aldolase protein
SGPL1 protein
KIAA1252 protein

Information sourced from Uniprot.org

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