Human SETD7 protein (Recombinant) (No-Tag) (STJP019756)

SKU:
STJP019756
£110.50 - £535.50
Processing The item has been added
Enquire For Bulk Order

Covered by St John's Laboratory Guarantee

Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SETD7-No-Tag protein was developed from e.coli and has a target region of No-Tag. For use in research applications.
Formulation: Liquid in 50mM Tris-HCl buffer (pH 7.5) containing 0.2M NaCl, 5mM DTT, 20%Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Gene Symbol: SETD7
Gene ID: 80854
Uniprot ID: SETD7_HUMAN
Immunogen Region: 1-366aa
Accession Number: NP_085151
Immunogen: Human
Immunogen Sequence: MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGE
Tissue Specificity Widely expressed. Expressed in pancreatic islets.
Function Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS.
Protein Name Histone-Lysine N-Methyltransferase Setd7
Histone H3-K4 Methyltransferase Setd7
H3-K4-Hmtase Setd7
Lysine N-Methyltransferase 7
Set Domain-Containing Protein 7
Set7/9
Database Links Reactome: R-HSA-3214841
Cellular Localisation Nucleus
Chromosome
Alternative Protein Names Histone-Lysine N-Methyltransferase Setd7 protein
Histone H3-K4 Methyltransferase Setd7 protein
H3-K4-Hmtase Setd7 protein
Lysine N-Methyltransferase 7 protein
Set Domain-Containing Protein 7 protein
Set7/9 protein
SETD7 protein
KIAA1717 protein
KMT7 protein
SET7 protein
SET9 protein

Information sourced from Uniprot.org

Related Products

Model Name Host Clonality Reactivity Application
STJP016332 Human SETD7 protein (Recombinant) (N-His) (STJP016332) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP008962 Human SETD7 protein (Recombinant) (N-His) (STJP008962) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP015162 Human PTHLH, no tag protein (Recombinant) (No tag) (STJP015162) E.coli ELISA/Immunogen/SDS-PAGE/WB
STJP006954 Human IGF1 protein (Recombinant) (No tag) (STJP006954) Yeast ELISA/Immunogen/SDS-PAGE/WB
STJP016584 Human FEN1 protein (Recombinant) (No-Tag) (STJP016584) E.coli SDS-PAGE

Related Products

!