Human Serum albumin/ALB protein (Recombinant) (C-His&Avi) {Biotin} (STJP020230)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human Serum Albumin Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.οΌIt contains Asp25-Leu609.
General Information
| Short Description | Recombinant-Human Serum albumin/ALB-C-His&Avi protein was developed in hek293 cells using the region Asp25-Leu609. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization. Contact us for customized product form or formulation. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | ALB |
| Gene ID | 213 |
| Uniprot ID | ALBU_HUMAN |
| Immunogen | Biotinylated Recombinant Human Serum Albumin Protein is expressed from Expi293 with His tag and Avi tag at the C-terminal.οΌIt contains Asp25-Leu609. |
| Immunogen Region | Asp25-Leu609 |
Additional Info
| Tissue Specificity | Plasma. |
| Post Translational Modifications | Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606. Glycated in diabetic patients. Phosphorylated by FAM20C in the extracellular medium. Acetylated on Lys-223 by acetylsalicylic acid. |
| Function | Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin. |
| Protein Name | Albumin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-159418Reactome: R-HSA-189451Reactome: R-HSA-189483Reactome: R-HSA-2168880Reactome: R-HSA-381426Reactome: R-HSA-8957275Reactome: R-HSA-8964058Reactome: R-HSA-9707564Reactome: R-HSA-9749641Reactome: R-HSA-9757110Reactome: R-HSA-9793528 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Albumin proteinALB proteinGIG20 proteinGIG42 proteinPRO0903 proteinPRO1708 proteinPRO2044 proteinPRO2619 proteinPRO2675 proteinUNQ696 proteinPRO1341 protein |
Information sourced from Uniprot.org