| Host: | Mammalian Cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Active-Human SERPING1-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | <0.1 EU/Mu g of the protein by the LAL method. |
| Gene Symbol: | SERPING1 |
| Gene ID: | 710 |
| Uniprot ID: | IC1_HUMAN |
| Immunogen Region: | Asn23-Ala500 |
| Immunogen: | Homo sapiens (Human) |
| Function | Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
| Protein Name | Plasma Protease C1 InhibitorC1 InhC1inhC1 Esterase InhibitorC1-Inhibiting FactorSerpin G1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-9657689Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Plasma Protease C1 Inhibitor proteinC1 Inh proteinC1inh proteinC1 Esterase Inhibitor proteinC1-Inhibiting Factor proteinSerpin G1 proteinSERPING1 proteinC1IN proteinC1NH protein |
Information sourced from Uniprot.org