Human Serpin A3/Alpha-1-antichymotrypsin protein (Recombinant) (His-Tag) (STJP016562)

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STJP016562
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Serpin A3/Alpha-1-antichymotrypsin-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: SERPINA3
Gene ID: 12
Uniprot ID: AACT_HUMAN
Immunogen Region: 24-423aa
Accession Number: NP_001076
Immunogen: Human
Immunogen Sequence: HPNSPLDEE NLTQENQDRG THVDLGLASA NVDFAFSLYK QLVLKAPDKN VIFSPLSIST ALAFLSLGAH NTTLTEILKG LKFNLTETSE AEIHQSFQHL LRTLNQSSDE LQLSMGNAMF VKEQLSLLDR FTEDAKRLYG SEAFATDFQD SAAAKKLIND YVKNGTRGKI TDLIKDLDSQ TMMVLVNYIF FKAKWEMPFD PQDTHQ
Tissue Specificity Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains.
Post Translational Modifications N- and O-glycosylated.
Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2.
Protein Name Alpha-1-Antichymotrypsin
Act
Cell Growth-Inhibiting Gene 24/25 Protein
Serpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-6798695
Cellular Localisation Secreted
Alternative Protein Names Alpha-1-Antichymotrypsin protein
Act protein
Cell Growth-Inhibiting Gene 24/25 Protein protein
Serpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less protein
SERPINA3 protein
AACT protein
GIG24 protein
GIG25 protein

Information sourced from Uniprot.org

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