| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SEPTIN8-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | SEPTIN8 |
| Gene ID: | 23176 |
| Uniprot ID: | SEPT8_HUMAN |
| Immunogen Region: | Gly26-Gly309 |
| Immunogen: | Homo sapiens (Human) |
| Function | Filament-forming cytoskeletal GTPase. May play a role in platelet secretion. Seems to participate in the process of SNARE complex formation in synaptic vesicles. Isoform 4: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. |
| Protein Name | Septin-8 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSynapseCell ProjectionAxonCytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembranePresynapseExpressed In Axons Of Immature NeuronsLocalizes To Synapses In Mature NeuronsIn PlateletsFound In Areas Surrounding Alpha-Granules |
| Alternative Protein Names | Septin-8 proteinSEPTIN8 proteinKIAA0202 proteinSEPT8 protein |
Information sourced from Uniprot.org