Name: Human Semaphorin-4D/SEMA4D/CD100 protein (Recombinant) (C-His) (STJP001081)
SKU: STJP001081
Availability: InStock

Human Semaphorin-4D/SEMA4D/CD100 protein (Recombinant) (C-His) (STJP001081)

SKU:

STJP001081

£97.50 - £291.50

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity:	Measured by its binding ability in a functional ELISA. Immobilized Human SEMA4D Protein at 1 Mu g/mL (100 Mu L/well) can bind CD100 Rabbit mAb with a linear range of 0.012-0.88 ng/mL.

Gene Symbol:	SEMA4D
Gene ID:	10507
Uniprot ID:	SEM4D_HUMAN
Immunogen:	Recombinant Human Semaphorin-4D/SEMA4D/CD100 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met22-Arg734) of human Semaphorin 4D (Accession #NP_006369.3) fused with a 6×His tag at the C-terminus.
Immunogen Sequence:	MAFAPIPRITWEHREVHLVQ FHEPDIYNYSALLLSEDKDT LYIGAREAVFAVNALNISEK QHEVYWKVSEDKKAKCAEKG KSKQTECLNYIRVLQPLSAT SLYVCGTNAFQPACDHLNLT SFKFLGKNEDGKGRCPFDPA HSYTSVMVDGELYSGTSYNF LGSEPIISRNSSHSPLRTEY AIPWLNEPSFVFADVIRKSP DSPDGEDDRVYFFFTEVSVE YEFVFRVLIPRIARVCKGD

Tissue Specificity	Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.
Function	Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system.induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.
Protein Name	Semaphorin-4d A8 Bb18 Gr3 Cd Antigen Cd100
Database Links	Reactome: R-HSA-416550 Reactome: R-HSA-416572 Reactome: R-HSA-416700
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Protein Names	Semaphorin-4d protein A8 protein Bb18 protein Gr3 protein Cd Antigen Cd100 protein SEMA4D protein C9orf164 protein CD100 protein SEMAJ protein

Information sourced from Uniprot.org

Model	Name	Host	Reactivity	Application
STJP001561	Human Semaphorin 4D/SEMA4D/CD100 protein (Recombinant) (C-His-Avi) {Biotin} (STJP001561)	HEK293
STJE0003564	Human SEMA4D (Semaphorin-4D) Sandwich ELISA Kit (STJE0003564)		Human	ELISA
STJP001392	Human Semaphorin-3G/SEMA3G protein (Recombinant) (C-His) (STJP001392)	HEK293 cells
STJP002003	Human Semaphorin-6A/SEMA6A protein (Recombinant) (C-His) (STJP002003)	HEK293 cells
STJP001254	Human Semaphorin-4A/SEMA4A protein (Recombinant) (C-hFc&His) (STJP001254)	HEK293 cells
STJP000819	Human MANF protein (Recombinant) (C-His) (STJP000819)	E. coli
STJP000855	Human CD4 protein (Recombinant) (C-His) (STJP000855)	HEK293 cells

Human Semaphorin-4D/SEMA4D/CD100 protein (Recombinant) (C-His) (STJP001081)