Host: |
HEK293 cells |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Recombinant-Human SELP/P-Selectin/CD62P-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Immunoreactivity: |
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When 5 x 10E4 cells/well are added to Human SELP coated plates (10 Mu g/mL with 100 Mu L/well) , > 80% cells will adhere after 1 hour |
Gene Symbol: |
SELP |
Gene ID: |
6403 |
Uniprot ID: |
LYAM3_HUMAN |
Immunogen: |
Recombinant Human SELP/P-Selectin/CD62P Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Trp42-Ala771) of human P-Selectin/CD62P (Accession #NP_002996.2) fused with a Fc, 6×His tag at the C-terminu |
Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. |
Protein Name | P-SelectinCd62 Antigen-Like Family Member PGranule Membrane Protein 140Gmp-140Leukocyte-Endothelial Cell Adhesion Molecule 3Lecam3Platelet Activation Dependent Granule-External Membrane ProteinPadgemCd Antigen Cd62p |
Database Links | Reactome: R-HSA-114608Reactome: R-HSA-202733 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Protein Names | P-Selectin proteinCd62 Antigen-Like Family Member P proteinGranule Membrane Protein 140 proteinGmp-140 proteinLeukocyte-Endothelial Cell Adhesion Molecule 3 proteinLecam3 proteinPlatelet Activation Dependent Granule-External Membrane Protein proteinPadgem proteinCd Antigen Cd62p proteinSELP proteinGMRP proteinGRMP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance