Human SECISBP2 protein (Recombinant) (N-His) (STJP009694)

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STJP009694
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SECISBP2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SECISBP2
Gene ID: 79048
Uniprot ID: SEBP2_HUMAN
Immunogen Region: Ser638-Leu854
Immunogen: Homo sapiens (Human)
Function mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine. Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling. (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation. (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur.
Protein Name Selenocysteine Insertion Sequence-Binding Protein 2
Secis-Binding Protein 2
Database Links Reactome: R-HSA-2408557
Cellular Localisation Isoform 1: Nucleus
Isoform 2: Mitochondrion
Alternative Protein Names Selenocysteine Insertion Sequence-Binding Protein 2 protein
Secis-Binding Protein 2 protein
SECISBP2 protein
SBP2 protein

Information sourced from Uniprot.org

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