| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human SEC13-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% Glycerol, 100mM NaCl |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC13 |
| Gene ID: | 6396 |
| Uniprot ID: | SEC13_HUMAN |
| Immunogen Region: | 1-322aa |
| Accession Number: | NP_899195 |
| Immunogen: | Human |
| Immunogen Sequence: |
| Function | Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum. As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex. |
| Protein Name | Protein Sec13 HomologGator2 Complex Protein Sec13Sec13-Like Protein 1Sec13-Related Protein |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-141444Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-204005Reactome: R-HSA-2132295Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-5663220Reactome: R-HSA-6784531Reactome: R-HSA-68877Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933Reactome: R-HSA-9639288Reactome: R-HSA-9648025Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | Cytoplasmic VesicleCopii-Coated Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideEndoplasmic Reticulum MembraneNucleusNuclear Pore ComplexLysosome MembraneIn InterphaseLocalizes At Both Sides Of The Npc |
| Alternative Protein Names | Protein Sec13 Homolog proteinGator2 Complex Protein Sec13 proteinSec13-Like Protein 1 proteinSec13-Related Protein proteinSEC13 proteinD3S1231E proteinSEC13A proteinSEC13L1 proteinSEC13R protein |
Information sourced from Uniprot.org