SDS-PAGE gel of recombinant human SDHAF1 protein under reducing conditions stained with Coomassie blue

Human SDHAF1 protein (Recombinant) (His-Tag) (STJP018969)

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STJP018969
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Short Description :Recombinant-Human SDHAF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) 30% Glycerol, 2mM DTT, 0.1mM PMSF
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SDHAF1
Gene ID:644096
Uniprot ID:SDHF1_HUMAN
Accession Number:NP_001036096
Immunogen:Human
Immunogen Region:1-115aa
Immunogen Sequence:MSRHSRL QRQVLSLYRD LLRAGRGKPG AEARVRAEFR QHAGLPRSDV LRIEYLYRRG RRQLQLLRSG HATAMGAFVR PRAPTGEPGG VGSQPDDGDS PRNPHDSTGA PETRPDGR
Tissue Specificity Ubiquitously expressed.
Function Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF3. Contributes to iron-sulfur cluster incorporation into SDHB by binding to SDHB and recruiting the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20.
Protein Name Succinate Dehydrogenase Assembly Factor 1 - Mitochondrial
Sdh Assembly Factor 1
Sdhaf1
Lyr Motif-Containing Protein 8
Database Links Reactome: R-HSA-9854311
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Succinate Dehydrogenase Assembly Factor 1 - Mitochondrial protein
Sdh Assembly Factor 1 protein
Sdhaf1 protein
Lyr Motif-Containing Protein 8 protein
SDHAF1 protein
LYRM8 protein

Information sourced from Uniprot.org

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