| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
33.2pg/mL |
| Detection Limit: |
78.1-5000pg/mL |
| Short Description: |
This SDHA Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
SDHA |
| Gene ID: |
6389 |
| Uniprot ID: |
SDHA_HUMAN |
| Sample Type: |
tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. Acetylated. Deacetylated by SIRT3. |
| Function | Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate. Can act as a tumor suppressor. |
| Protein Name | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - MitochondrialFlavoprotein Subunit Of Complex IiFpMalate Dehydrogenase Quinone Flavoprotein Subunit |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403Reactome: R-HSA-9854311 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative ELISA Names | Succinate Dehydrogenase Ubiquinone Flavoprotein Subunit - Mitochondrial ELISA kitFlavoprotein Subunit Of Complex Ii ELISA kitFp ELISA kitMalate Dehydrogenase Quinone Flavoprotein Subunit ELISA kitSDHA ELISA kitSDH2 ELISA kitSDHF ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
