| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.113ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This SCNN1g Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | SCNN1G |
| Gene ID: | 6340 |
| Uniprot ID: | SCNNG_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Expressed in kidney (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit Gamma Epithelial Na(+ Channel Subunit Gamma Enacg Gamma-Enac Gamma-Nach Nonvoltage-Gated Sodium Channel 1 Subunit Gamma Scneg |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Apical Membrane Of Epithelial Cells |
| Alternative ELISA Names | Amiloride-Sensitive Sodium Channel Subunit Gamma ELISA kit Epithelial Na(+ Channel Subunit Gamma ELISA kit Enacg ELISA kit Gamma-Enac ELISA kit Gamma-Nach ELISA kit Nonvoltage-Gated Sodium Channel 1 Subunit Gamma ELISA kit Scneg ELISA kit SCNN1G ELISA kit |
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Information sourced from Uniprot.org
