| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.107ng/mL |
| Detection Limit: | 0.312-20ng/mL |
| Short Description: | This SCNN1b Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | SCNN1B |
| Gene ID: | 6338 |
| Uniprot ID: | SCNNB_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Detected in placenta, lung and kidney. Expressed in kidney (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. N-glycosylated. N-glycosylation is required for interaction with BPIFA1. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit Beta Beta-Nach Epithelial Na(+ Channel Subunit Beta Beta-Enac Enacb Nonvoltage-Gated Sodium Channel 1 Subunit Beta Scneb |
| Database Links | Reactome: R-HSA-2672351 Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Membrane Apical Membrane Of Epithelial Cells |
| Alternative ELISA Names | Amiloride-Sensitive Sodium Channel Subunit Beta ELISA kit Beta-Nach ELISA kit Epithelial Na(+ Channel Subunit Beta ELISA kit Beta-Enac ELISA kit Enacb ELISA kit Nonvoltage-Gated Sodium Channel 1 Subunit Beta ELISA kit Scneb ELISA kit SCNN1B ELISA kit |
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Information sourced from Uniprot.org
