Human Sclerostin/SOST protein (Recombinant) (N-His) (STJP001180)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human Sclerostin/SOST Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Tyr213) of human SOST/Sclerostin (Accession #NP_079513.1) fused with a 8ΓHis tag at the N-terminus.
General Information
| Short Description | Recombinant-Human Sclerostin/SOST-N-His protein was developed in hek293 cells using the region Gln24-Tyr213. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20Β°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 0.1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | SOST |
| Gene ID | 50964 |
| Uniprot ID | SOST_HUMAN |
| Immunogen | Recombinant Human Sclerostin/SOST Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Tyr213) of human SOST/Sclerostin (Accession #NP_079513.1) fused with a 8ΓHis tag at the N-terminus. |
| Immunogen Region | Gln24-Tyr213 |
| Immunogen Sequence | QGWQAFKNDATEIIPELGEY PEPPPELENNKTMNRAENGG RPPHHPFETKDVSEYSCREL HFTRYVTDGPCRSAKPVTEL VCSGQCGPARLLPNAIGRGK WWRPSGPDFRCIPDRYRAQR VQLLCPGGEAPRARKVRLVA SCKCKRLTRFHNQSELKDFG TEAARPQKGRKPRPRARSAK ANQAELENAY |
Additional Info
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Sclerostin proteinSOST proteinUNQ2976 proteinPRO7455 proteinPRO7476 protein |
Information sourced from Uniprot.org