| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
SOST |
| Gene ID: |
50964 |
| Uniprot ID: |
SOST_HUMAN |
| Immunogen: |
Recombinant Human Sclerostin/SOST Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Tyr213) of human SOST/Sclerostin (Accession #NP_079513.1) fused with a 8×His tag at the N-terminus. |
| Immunogen Sequence: |
QGWQAFKNDATEIIPELGEY PEPPPELENNKTMNRAENGG RPPHHPFETKDVSEYSCREL HFTRYVTDGPCRSAKPVTEL VCSGQCGPARLLPNAIGRGK WWRPSGPDFRCIPDRYRAQR VQLLCPGGEAPRARKVRLVA SCKCKRLTRFHNQSELKDFG TEAARPQKGRKPRPRARSAK ANQAELENAY |
| Function | Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
| Protein Name | Sclerostin |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Sclerostin proteinSOST proteinUNQ2976 proteinPRO7455 proteinPRO7476 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
