Human SCG3 protein (Recombinant) (His-Tag) (STJP018318)

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STJP018318
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Short Description :Recombinant-Human SCG3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 20% Glycerol, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SCG3
Gene ID:29106
Uniprot ID:SCG3_HUMAN
Accession Number:NP_037375
Immunogen:Human
Immunogen Region:20-468aa
Immunogen Sequence:FPKPGGS QDKSLHNREL SAERPLNEQI AEAEEDKIKK TYPPENKPGQ SNYSFVDNLN LLKAITEKEK IEKERQSIRS SPLDNKLNVE DVDSTKNRKL IDDYDSTKSG LDHKFQDDPD GLHQLDGTPL TAEDIVHKIA ARIYEENDRA VFDKIVSKLL NLGLITESQA HTLEDEVAEV LQKLISKEAN NYEEDPNKPT SWTENQ
Tissue Specificity Detected in urine (at protein level). Expressed in brain, heart, kidney, liver and skeletal muscle.
Post Translational Modifications O-glycosylated.
Function Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway.
Protein Name Secretogranin-3
Secretogranin Iii
Sgiii
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Secretory Vesicle Membrane
Peripheral Membrane Protein
Secreted
Associated With The Secretory Granule Membrane Through Direct Binding To Cholesterol-Enriched Lipid Rafts
Alternative Protein Names Secretogranin-3 protein
Secretogranin Iii protein
Sgiii protein
SCG3 protein
UNQ2502 protein
PRO5990 protein

Information sourced from Uniprot.org

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