Human SCARB1/SR-BI/CLA-1/SRB1 protein (Recombinant) (C-His) (STJP006423)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human SCARB1/SR-BI/CLA-1/SRB1-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | SCARB1 |
| Gene ID | 949 |
| Uniprot ID | SCRB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro33-Tyr443 |
Additional Info
| Post Translational Modifications | N-glycosylated. The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds. |
| Function | Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry. Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate. (Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus. (Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding. |
| Protein Name | Scavenger Receptor Class B Member 1Srb1Cd36 And Limpii Analogous 1Cla-1Cd36 Antigen-Like 1Collagen Type I Receptor - Thrombospondin Receptor-Like 1Sr-BiCd Antigen Cd36 |
| Database Links | Reactome: R-HSA-3000471 Q8WTV0-2Reactome: R-HSA-8964011 Q8WTV0-2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembraneCaveolaPredominantly Localized To Cholesterol And Sphingomyelin-Enriched Domains Within The Plasma MembraneCalled Caveolae |
| Alternative Protein Names | Scavenger Receptor Class B Member 1 proteinSrb1 proteinCd36 And Limpii Analogous 1 proteinCla-1 proteinCd36 Antigen-Like 1 proteinCollagen Type I Receptor - Thrombospondin Receptor-Like 1 proteinSr-Bi proteinCd Antigen Cd36 proteinSCARB1 proteinCD36L1 proteinCLA1 protein |
Information sourced from Uniprot.org