Human SBF2/MTMR13 protein (Recombinant) (N-GST & C-His) (STJP008498)

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STJP008498
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Covered by St John's Laboratory Guarantee

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SBF2/MTMR13-N-GST & C-His protein was developed from e. coli and has a target region of N-GST & C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SBF2
Gene ID: 81846
Uniprot ID: MTMRD_HUMAN
Immunogen Region: Gly775-Glu882
Immunogen: Homo sapiens (Human)
Function Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate.
Protein Name Myotubularin-Related Protein 13
Inactive Phosphatidylinositol 3-Phosphatase 13
Set-Binding Factor 2
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-8876198
Cellular Localisation Cytoplasm
Perinuclear Region
Membrane
Peripheral Membrane Protein
Endosome Membrane
Cell Projection
Axon
Associated With Membranes
Localizes To Vacuoles In Hypo-Osmotic Conditions
Membrane Localization Is Likely To Be Mediated Via Its Interaction With Mtmr2
Alternative Protein Names Myotubularin-Related Protein 13 protein
Inactive Phosphatidylinositol 3-Phosphatase 13 protein
Set-Binding Factor 2 protein
SBF2 protein
CMT4B2 protein
KIAA1766 protein
MTMR13 protein

Information sourced from Uniprot.org

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