Human SASH1 protein (Recombinant) (N-His) (STJP010766)

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STJP010766
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human SASH1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: SASH1
Gene ID: 23328
Uniprot ID: SASH1_HUMAN
Immunogen Region: Val1091-Met1247
Immunogen: Homo sapiens (Human)
Function Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
Protein Name Sam And Sh3 Domain-Containing Protein 1
Proline-Glutamate Repeat-Containing Protein
Cellular Localisation Cytoplasm
Alternative Protein Names Sam And Sh3 Domain-Containing Protein 1 protein
Proline-Glutamate Repeat-Containing Protein protein
SASH1 protein
KIAA0790 protein
PEPE1 protein

Information sourced from Uniprot.org

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