| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.2 Mu m filtered solution of 20mM PBS, 150mM NaCl, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
< 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: |
S100B |
| Gene ID: |
6285 |
| Uniprot ID: |
S100B_HUMAN |
| Immunogen Region: |
Met1-Glu92 |
| Immunogen: |
Recombinant Human S100-B Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Glu92) of human S100 Calcium Binding Protein B/S100B (Accession #P04271) fused with an initial Met at the N-terminus |
| Immunogen Sequence: |
QRFAQAQQQLPLESLGWDVA ELQLNHTGPQQDPRLYWQGG PALGRSFLHGPELDKGQLRI HRDGIYMVHIQVTLAICSST TASRHHPTTLAVGICSPASR SISLLRLSFHQGCTIASQRL TPLARGDTLCTNLTGTLLPS RNTDETFFGVQWVRP |
| Tissue Specificity | Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. |
| Function | Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation. Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. |
| Protein Name | Protein S100-BS-100 Protein Beta ChainS-100 Protein Subunit BetaS100 Calcium-Binding Protein B |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-445989Reactome: R-HSA-879415Reactome: R-HSA-933542 |
| Cellular Localisation | CytoplasmNucleusSecretedSecretion Into The Medium Is Promoted By Interaction With Isoform Clstn3beta Of Clstn3 |
| Alternative Protein Names | Protein S100-B proteinS-100 Protein Beta Chain proteinS-100 Protein Subunit Beta proteinS100 Calcium-Binding Protein B proteinS100B protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
