SDS-PAGE gel showing recombinant human RYBP protein 3ug under reducing conditions with Coomassie blue stain

Human RYBP protein (Recombinant) (His-Tag) (STJP017710)

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STJP017710
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Short Description :Recombinant-Human RYBP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 1mM DTT, 100mM NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:RYBP
Gene ID:23429
Uniprot ID:RYBP_HUMAN
Accession Number:NP_036366
Immunogen:Human
Immunogen Region:1-228aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTMGDK KSPTRPKRQA KPAADEGFWD CSVCTFRNSA EAFKCSICDV RKGTSTRKPR INSQLVAQQV AQQYATPPPP KKEKKEKVEK QDKEKPEKDK EISPSVTKKN TNKKTKPKSD ILKDPPSEAN SIQSANATTK TSETNHTSRP RLKNVDRSTA QQLAVTVGNV TVIITDFKEK TRSSSTSSST VTSSAGSEQQ NQSSSGSE
Tissue Specificity Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level). Widely expressed with highest levels in lymphoid tissues and placenta.
Post Translational Modifications Monoubiquitinated.
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3.
Protein Name Ring1 And Yy1-Binding Protein
Apoptin-Associating Protein 1
Apap-1
Death Effector Domain-Associated Factor
Ded-Associated Factor
Yy1 And E4tf1-Associated Factor 1
Database Links Reactome: R-HSA-8939243
Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Cytoplasm
Nucleoplasm
Primarily Found In The Nucleus
Detected In A Punctate Pattern Likely To Represent Polycomb Group (Pcg) Bodies
Alternative Protein Names Ring1 And Yy1-Binding Protein protein
Apoptin-Associating Protein 1 protein
Apap-1 protein
Death Effector Domain-Associated Factor protein
Ded-Associated Factor protein
Yy1 And E4tf1-Associated Factor 1 protein
RYBP protein
DEDAF protein
YEAF1 protein

Information sourced from Uniprot.org

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