Human RTN4IP1 protein (Recombinant) (His-Tag) (STJP017483)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RTN4IP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 30% Glycerol, 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4IP1 |
| Gene ID | 84816 |
| Uniprot ID | RT4I1_HUMAN |
| Accession Number | NP_116119 |
| Immunogen | Human |
| Immunogen Region | 41-396aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSTVMPAWV IDKYGKNEVL RFTQNMMMPI IHYPNEVIVK VHAASVNPID VNMRSGYGAT ALNMKRDPLH VKIKGEEFPL TLGRDVSGVV MECGLDVKYF KPGDEVWAAV PPWKQGTLSE FVVVSGNEVS HKPKSLTHTQ AASLPYVALT AWSAINKVGG LNDKNCTGKR VLILGASGGV GTFAIQVMKA WDAHVTAVCS QDASELVR |
Additional Info
| Tissue Specificity | Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta. |
| Function | NAD(P)H oxidoreductase involved in the ubiquinone biosynthetic pathway. Required for the O-methyltransferase activity of COQ3. Able to catalyze the oxidoreduction of 3-demethylubiquinone into 3-demethylubiquinol in vitro. However, it is unclear if 3-demethylubiquinone constitutes a substrate in vivo. May also play a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. |
| Protein Name | Nad(Ph Oxidoreductase Rtn4ip1 - MitochondrialNogo-Interacting Mitochondrial ProteinReticulon-4-Interacting Protein 1 |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixMitochondrion Outer MembraneMainly Localizes To The Mitochondrial MatrixAlso Colocalizes With The Endoplasmic Reticulum Hspa5 At Spots Corresponding To Contacts With Mitochondria |
| Alternative Protein Names | Nad(Ph Oxidoreductase Rtn4ip1 - Mitochondrial proteinNogo-Interacting Mitochondrial Protein proteinReticulon-4-Interacting Protein 1 proteinRTN4IP1 proteinNIMP protein |
Information sourced from Uniprot.org