| Function | Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP.(B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A.(C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. Likely functions in some aspects of cellular RNA processing. Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury. |
| Protein Name | Rna 3'-Terminal Phosphate CyclaseRna CyclaseRna-3'-Phosphate CyclaseRna Terminal Phosphate Cyclase Domain-Containing Protein 1Rtc Domain-Containing Protein 1 |
| Cellular Localisation | NucleusNucleoplasm |
| Alternative Protein Names | Rna 3'-Terminal Phosphate Cyclase proteinRna Cyclase proteinRna-3'-Phosphate Cyclase proteinRna Terminal Phosphate Cyclase Domain-Containing Protein 1 proteinRtc Domain-Containing Protein 1 proteinRTCA proteinRPC proteinRPC1 proteinRTC1 proteinRTCD1 protein |
Information sourced from Uniprot.org
