Human RRM2B protein (Recombinant) (N-His) (STJP005626)

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STJP005626
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RRM2B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RRM2B
Gene ID: 50484
Uniprot ID: RIR2B_HUMAN
Immunogen Region: Met1-Phe351
Immunogen: Homo sapiens (Human)
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
Protein Name Ribonucleoside-Diphosphate Reductase Subunit M2 B
Tp53-Inducible Ribonucleotide Reductase M2 B
P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein
P53r2
Database Links Reactome: R-HSA-499943
Reactome: R-HSA-5628897
Cellular Localisation Cytoplasm
Nucleus
Translocates From Cytoplasm To Nucleus In Response To Dna Damage
Alternative Protein Names Ribonucleoside-Diphosphate Reductase Subunit M2 B protein
Tp53-Inducible Ribonucleotide Reductase M2 B protein
P53-Inducible Ribonucleotide Reductase Small Subunit 2-Like Protein protein
P53r2 protein
RRM2B protein
P53R2 protein

Information sourced from Uniprot.org

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