SDS-PAGE gel of recombinant human RRAS3 MRAS protein under reducing conditions stained with Coomassie blue

Human RRAS3/MRAS protein (Recombinant) (His-Tag) (STJP017458)

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STJP017458
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Short Description :Recombinant-Human RRAS3/MRAS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 5mM DTT, 40% Glycerol, 200mM NaCl, 2mM EDTA
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:MRAS
Gene ID:22808
Uniprot ID:RASM_HUMAN
Accession Number:NP_036351.3
Immunogen:Human
Immunogen Region:1-205aa
Immunogen Sequence: MATSAVPSDN LPTYKLVVVG DGGVGKSALT IQFFQKIFVP DYDPTIEDSY LKHTEIDNQW AILDVLDTAG QEEFSAMREQ YMRTGDGFLI VYSVTDKASF EHVDRFHQLI LRVKDRESFP MILVANKVDL MHLRKITREQ GKEMATKHNI PYIETSAKDP PLNVDKAFHD LVRVIRQQIP EKSQKKKKKT KWRGDRATGT HKLQC
Tissue Specificity Expression highly restricted to the brain and heart.
Function Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.
Protein Name Ras-Related Protein M-Ras
Ras-Related Protein R-Ras3
Database Links Reactome: R-HSA-5673000
Reactome: R-HSA-9726840
Reactome: R-HSA-9726842
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Alternative Protein Names Ras-Related Protein M-Ras protein
Ras-Related Protein R-Ras3 protein
MRAS protein
RRAS3 protein

Information sourced from Uniprot.org

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