Human RPN1 protein (Recombinant) (N-His) (STJP003683)

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STJP003683
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RPN1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RPN1
Gene ID: 6184
Uniprot ID: RPN1_HUMAN
Immunogen Region: Ala24-Ser179
Immunogen: Homo sapiens (Human)
Post Translational Modifications Ubiquitinated by the ECS(ASB11) complex. Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.
Function Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
Protein Name Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1
Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 Kda Subunit
Ribophorin I
Rpn-I
Ribophorin-1
Database Links Reactome: R-HSA-1799339
Reactome: R-HSA-446203
Reactome: R-HSA-9694548
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Protein Names Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit 1 protein
Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase 67 Kda Subunit protein
Ribophorin I protein
Rpn-I protein
Ribophorin-1 protein
RPN1 protein

Information sourced from Uniprot.org

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