| Host: |
HEK293 cells |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human ROR1-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA. Immobilized Human ROR1 Protein at 1 Mu g/mL (100 Mu L/well) can bind ROR1 Rabbit pAb with a linear range of 0.977-5.7 ng/mL. |
| Gene Symbol: |
ROR1 |
| Gene ID: |
4919 |
| Uniprot ID: |
ROR1_HUMAN |
| Immunogen Region: |
Gln30-Glu403 |
| Immunogen: |
Recombinant Human ROR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln30-Glu403) of human ROR1 (Accession #NP_005003.2) fused with a Fc, 6×His tag at the C-terminus. |
| Tissue Specificity | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 1 proteinROR1 proteinNTRKR1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
