| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA.Immobilized Human ROR1 Protein at 1 Mu g/mL (100 Mu L/well) can bind ROR1 Rabbit pAb with a linear range of 0.977-5.7 ng/mL. |
| Gene Symbol: | ROR1 |
| Gene ID: | 4919 |
| Uniprot ID: | ROR1_HUMAN |
| Immunogen Region: | Gln30-Glu403 |
| Immunogen: | Recombinant Human ROR1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln30-Glu403) of human ROR1 (Accession #NP_005003.2) fused with a Fc, 6×His tag at the C-terminus. |
| Immunogen Sequence: | QETELSVSAELVPTSSWNIS SELNKDSYLTLDEPMNNITT SLGQTAELHCKVSGNPPPTI RWFKNDAPVVQEPRRLSFRS TIYGSRLRIRNLDTTDTGYF QCVATNGKEVVSSTGVLFVK FGPPPTASPGYSDEYEEDGF CQPYRGIACARFIGNRTVYM ESLHMQGEIENQITAAFTMI GTSSHLSDKCSQFAIPSLCH YAFPYCDETSSVPKPRDLCR DECEILENVLCQTEYIFAR |
| Tissue Specificity | Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
| Function | Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling. |
| Protein Name | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1Neurotrophic Tyrosine Kinase - Receptor-Related 1 |
| Database Links | Reactome: R-HSA-5140745 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxon |
| Alternative Protein Names | Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 proteinNeurotrophic Tyrosine Kinase - Receptor-Related 1 proteinROR1 proteinNTRKR1 protein |
Information sourced from Uniprot.org
