Human RNF6 protein (Recombinant) (N-His-SUMO) (STJP007973)

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STJP007973
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RNF6-N-His-SUMO protein was developed from e. coli and has a target region of N-His-SUMO. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RNF6
Gene ID: 6049
Uniprot ID: RNF6_HUMAN
Immunogen Region: Thr580-Gly685
Immunogen: Homo sapiens (Human)
Function E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation.
Protein Name E3 Ubiquitin-Protein Ligase Rnf6
Database Links Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasm
Cell Projection
Axon
Pml Body
Localizes To The Pml Nuclear Bodies In Sertoli Cells
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rnf6 protein
RNF6 protein
SPG2 protein

Information sourced from Uniprot.org

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