| Short Description : | Recombinant-Human RNF6-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | RNF6 |
| Gene ID: | 6049 |
| Uniprot ID: | RNF6_HUMAN |
| Immunogen: | Homo sapiens (Human) |
| Immunogen Region: | Thr580-Gly685 |
| Function | E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Mediates polyubiquitination of QKI in macrophages, leading to its degradation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf6 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionAxonPml BodyLocalizes To The Pml Nuclear Bodies In Sertoli Cells |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rnf6 proteinRNF6 proteinSPG2 protein |
Information sourced from Uniprot.org