Human RNF4 protein (Recombinant) (His-Tag) (STJP017869)

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STJP017869
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RNF4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 30% Glycerol, 1mM DTT
Concentration: 0.5 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: RNF4
Gene ID: 6047
Uniprot ID: RNF4_HUMAN
Immunogen Region: 1-190aa
Accession Number: NP_001171938.1
Immunogen: Human
Immunogen Sequence: MSTRKRR GGAINSRQAQ KRTREATSTP EISLEAEPIE LVETAGDEIV DLTCESLEPV VVDLTHNDSV VIVDERRRPR RNARRLPQDH ADSCVVSSDD EELSRDRDVY VTTHTPRNAR DEGATGLRPS GTVSCPICMD GYSEIVQNGR LIVSTECGHV FCSQCLRDSL KNANTCPTCR KKINHKRYHP IYI
Tissue Specificity Widely expressed at low levels in many tissues.highly expressed in testis.
Post Translational Modifications Sumoylated.conjugated by one or two SUMO1 moieties. Autoubiquitinated.
Function E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
Protein Name E3 Ubiquitin-Protein Ligase Rnf4
Ring Finger Protein 4
Small Nuclear Ring Finger Protein
Protein Snurf
Database Links Reactome: R-HSA-5693607
Reactome: R-HSA-983168
Cellular Localisation Cytoplasm
Nucleus
Pml Body
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rnf4 protein
Ring Finger Protein 4 protein
Small Nuclear Ring Finger Protein protein
Protein Snurf protein
RNF4 protein
SNURF protein
RES4-26 protein

Information sourced from Uniprot.org

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