| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf113aCwc24 HomologRing Finger Protein 113aZinc Finger Protein 183 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus SpeckleColocalizes With Ascc2 In Nuclear Foci After Dna Damage By Alkylating AgentsIn The Absence Of Dna DamageColocalizes With The Spliceosome Components Snrnp200/Brr2 And Prpf8 In Nuclear Speckles |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rnf113a proteinCwc24 Homolog proteinRing Finger Protein 113a proteinZinc Finger Protein 183 proteinRNF113A proteinRNF113 proteinZNF183 protein |
Information sourced from Uniprot.org
