Tissue Specificity | Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut. Expressed in liver, kidney, skeletal muscle and heart. |
Post Translational Modifications | |
Function | Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium. Causes loss of bacterial membrane integrity. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
Protein Name | Ribonuclease 7Rnase 7Skin-Derived Antimicrobial Protein 2Sap-2 |
Database Links | Reactome: R-HSA-6803157 |
Cellular Localisation | SecretedDetected In Urine |
Alternative ELISA Names | Ribonuclease 7 ELISA kitRnase 7 ELISA kitSkin-Derived Antimicrobial Protein 2 ELISA kitSap-2 ELISA kitRNASE7 ELISA kitUNQ2516 ELISA kitPRO6006 ELISA kit |
output | |
Information sourced from Uniprot.org