| Host: | Mammalian Cells |
| Applications: | ELISA/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human RNASE6-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Conjugation: | Unconjugated |
| Formulation: | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 150mM NaCl, 1mM DTT, 10% Glycerol, pH 7.5. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | < 1 EU/µg as determined by LAL test. |
| Gene Symbol: | RNASE6 |
| Gene ID: | 6039 |
| Uniprot ID: | RNAS6_HUMAN |
| Immunogen Region: | Trp24-Leu150 |
| Immunogen: | Homo sapiens (Human) |
| Function | Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria. Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity. |
| Protein Name | Ribonuclease K6Rnase K6 |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedLysosomeCytoplasmic Granule |
| Alternative Protein Names | Ribonuclease K6 proteinRnase K6 proteinRNASE6 proteinRNS6 protein |
Information sourced from Uniprot.org
