| Function | Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates. Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination. Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc10Rna Polymerase Iii Subunit C10Dna-Directed Rna Polymerase Iii Subunit KRna Polymerase Iii 12.5 Kda SubunitRpc12.5Rna Polymerase Iii Subunit C11Hsc11pRpc11Hrpc11 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Dna-Directed Rna Polymerase Iii Subunit Rpc10 proteinRna Polymerase Iii Subunit C10 proteinDna-Directed Rna Polymerase Iii Subunit K proteinRna Polymerase Iii 12.5 Kda Subunit proteinRpc12.5 proteinRna Polymerase Iii Subunit C11 proteinHsc11p proteinRpc11 proteinHrpc11 proteinPOLR3K proteinRPC11 proteinMy010 protein |
Information sourced from Uniprot.org
