Human RIOK3 protein (Recombinant) (N-His) (STJP008338)

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STJP008338
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RIOK3-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RIOK3
Gene ID: 8780
Uniprot ID: RIOK3_HUMAN
Immunogen Region: Ser247-Glu519
Immunogen: Homo sapiens (Human)
Post Translational Modifications Autophosphorylated (in vitro).
Function Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.
Protein Name Serine/Threonine-Protein Kinase Rio3
Rio Kinase 3
Sudd Homolog
Database Links Reactome: R-HSA-6791226
Cellular Localisation Cytoplasm
Alternative Protein Names Serine/Threonine-Protein Kinase Rio3 protein
Rio Kinase 3 protein
Sudd Homolog protein
RIOK3 protein
SUDD protein

Information sourced from Uniprot.org

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