Human Riboflavin kinase/RFP protein (Recombinant) (His-Tag) (STJP016501)

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STJP016501
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Riboflavin kinase/RFP-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: RFK
Gene ID: 55312
Uniprot ID: RIFK_HUMAN
Immunogen Region: 1-162aa
Accession Number: NP_060809
Immunogen: Human
Immunogen Sequence: MPRADCIMRH LPYFCRGQVV RGFGRGSKQL GIPTANFPEQ VVDNLPADIS TGIYYGWASV GSGDVHKMVV SIGWNPYYKN TKKSMETHIM HTFKEDFYGE ILNVAIVGYL RPEKNFDSLE SLISAIQGDI EEAKKRLELP EHLKIKEDNF FQVSKSKIMN GH
Tissue Specificity Detected in brain, placenta and urinary bladder.
Function Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.
Protein Name Riboflavin Kinase
Atp -Riboflavin 5'-Phosphotransferase
Flavokinase
Database Links Reactome: R-HSA-196843
Cellular Localisation Cytoplasm
Alternative Protein Names Riboflavin Kinase protein
Atp -Riboflavin 5'-Phosphotransferase protein
Flavokinase protein
RFK protein

Information sourced from Uniprot.org

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