Human RELN protein (Recombinant) (N-His) (STJP005077)

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STJP005077
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RELN-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RELN
Gene ID: 5649
Uniprot ID: RELN_HUMAN
Immunogen Region: Asp2978-Val3373
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated and to a lesser extent also O-glycosylated.
Function Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.
Protein Name Reelin
Database Links Reactome: R-HSA-8866376
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Reelin protein
RELN protein

Information sourced from Uniprot.org

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