Human REC8 protein (Recombinant) (N-His-SUMO & C-Strep) (STJP007608)

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STJP007608
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human REC8-N-His-SUMO & C-Strep protein was developed from e. coli and has a target region of N-His-SUMO & C-Strep. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: REC8
Gene ID: 9985
Uniprot ID: REC8_HUMAN
Immunogen Region: Leu470-His547
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylated.
Function Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
Protein Name Meiotic Recombination Protein Rec8 Homolog
Cohesin Rec8p
Database Links Reactome: R-HSA-1221632
Cellular Localisation Nucleus
Chromosome
Centromere
In Meiotic Chromosomes
Localized Along Axial Elements In Prophase From The Leptotene To Diplotene Stages
At Later Prophase Stages
Diakinesis And Metaphase I
Localized Along Interstitial Axes Of Chromosomes Including Both Centromere And Arm Regions
No Longer Detected In Arm Regions In Anaphase I But Persists On Centromere Regions Until Metaphase Ii
Localized To Centromeres And Spindle Poles In Endopolyploid Tumor Cells
Alternative Protein Names Meiotic Recombination Protein Rec8 Homolog protein
Cohesin Rec8p protein
REC8 protein
REC8L1 protein

Information sourced from Uniprot.org

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