Human RDH12 protein (Recombinant) (N-His) (STJP015203)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human RDH12-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | RDH12 |
| Gene ID | 145226 |
| Uniprot ID | RDH12_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Thr33-Glu316 |
Additional Info
| Function | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. |
| Protein Name | Retinol Dehydrogenase 12All-Trans And 9-Cis Retinol DehydrogenaseShort Chain Dehydrogenase/Reductase Family 7c Member 2 |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-9918440 |
| Cellular Localisation | Endoplasmic Reticulum Membrane |
| Alternative Protein Names | Retinol Dehydrogenase 12 proteinAll-Trans And 9-Cis Retinol Dehydrogenase proteinShort Chain Dehydrogenase/Reductase Family 7c Member 2 proteinRDH12 proteinSDR7C2 protein |
Information sourced from Uniprot.org