SDS-PAGE gel of recombinant human RDH12 protein under reducing conditions stained with Coomassie blue

Human RDH12 protein (Recombinant) (His-Tag) (STJP017494)

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STJP017494
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Short Description :Recombinant-Human RDH12-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.25 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT, 40% Glycerol, 0.2M NaCl
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:RDH12
Gene ID:145226
Uniprot ID:RDH12_HUMAN
Accession Number:NP_689656.2
Immunogen:Human
Immunogen Region:39-316aa
Immunogen Sequence:GKVVV ITGANTGIGK ETARELASRG ARVYIACRDV LKGESAASEI RVDTKNSQVL VRKLDLSDTK SIRAFAEGFL AEEKQLHILI NNAGVMMCPY SKTADGFETH LGVNHLGHFL LTYLLLERLK VSAPARVVNV SSVAHHIGKI PFHDLQSEKR YSRGFAYCHS KLANVLFTRE LAKRLQGTGV TTYAVHPGVV RSELVR
Tissue Specificity Widely expressed, mostly in retina, kidney, brain, skeletal muscle, pancreas and stomach.
Function Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids.
Protein Name Retinol Dehydrogenase 12
All-Trans And 9-Cis Retinol Dehydrogenase
Short Chain Dehydrogenase/Reductase Family 7c Member 2
Database Links Reactome: R-HSA-2453902
Reactome: R-HSA-9918440
Cellular Localisation Endoplasmic Reticulum Membrane
Alternative Protein Names Retinol Dehydrogenase 12 protein
All-Trans And 9-Cis Retinol Dehydrogenase protein
Short Chain Dehydrogenase/Reductase Family 7c Member 2 protein
RDH12 protein
SDR7C2 protein

Information sourced from Uniprot.org

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