| Post Translational Modifications | Phosphorylation at Ser-734 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. |
| Function | Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways. Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway through induction of RB1 expression. Plays a crucial role in muscular differentiation. Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis. |
| Protein Name | Rb1-Inducible Coiled-Coil Protein 1Fak Family Kinase-Interacting Protein Of 200 KdaFip200 |
| Database Links | Reactome: R-HSA-1632852 |
| Cellular Localisation | NucleusCytoplasmCytosolPreautophagosomal StructureLysosomeUnder Starvation ConditionsIs Localized To Puncate Structures Primarily Representing The Isolation Membrane That Sequesters A Portion Of The Cytoplasm Resulting In The Formation Of An Autophagosome |
| Alternative Protein Names | Rb1-Inducible Coiled-Coil Protein 1 proteinFak Family Kinase-Interacting Protein Of 200 Kda proteinFip200 proteinRB1CC1 proteinKIAA0203 proteinRBICC protein |
Information sourced from Uniprot.org
